Latest News:  

English>>Life & Culture

Researchers find genes behind aggressive endometrial cancer


15:07, January 29, 2013

(File photo)

WASHINGTON, Jan. 28 (Xinhua) -- A team of U.S. researchers have identified a number of new genes that are frequently mutated in uterine serous carcinoma (USC) -- a chemo-resistant, aggressive form of endometrial cancer, according to a study published online Monday in Proceedings of the National Academy of Sciences.

The team collected tumors from 57 women affected with USC to try to determine the molecular basis of the tumor's aggressive behavior. They sequenced all the genes from the tumors and identified mutations that are crucial for these tumors to grow. The team also studied the copy number variations -- genes that are not mutated but are amplified in the tumors to give them a growth advantage over normal tissues.

The newly-identified cancer-related genes included two -- CHD4 and MBD3 -- that are found in the same protein complex and play a role in remodeling the genome to allow certain regions to be turned on and off. The discovery of a third gene, TAF1, was a surprise to researchers because it is a core component of the machinery responsible for transcribing a large fraction of the protein coding genes in the human genome.

"We have clearly identified the mutations that are responsible for USC tumors," said senior author of the study Alessandro Santin, professor at Yale School of Medicine. "This finding points to new pathways that could be important in developing therapies down the road."

Endometrial cancer is the most prevalent gynecologic tumor in women, with over 47,000 newly diagnosed cases and about 8,000 deaths in 2012 in the United States alone. Patients with type I endometrial cancer tumors generally have a good outcome, but those with type II, or USC, have more relapses and deaths, and the disease is more aggressive.

We recommend:

Beijing is in silver and white

Girlhood photos of Chinese stars revealed

A trip to sunshine sanctuary in Beihai

How sweet! Stunning pure ad girls

China's largest 'capsule hotel' opens in Qingdao

La Perla Spring Summer 2013 Lingerises

A young artist's life with wolf cub

Banquets at Diaoyutai State Guesthouse

Olympic medalist Michelle Kwan marries


Related Reading

Leave your comment0 comments

  1. Name


Selections for you

  1. Submarine flotilla in torpedo rapid-support

  2. Soldiers in emergency military drill

  3. The world in photos (2013.1.21-1.27)

  4. Panda 'Yaya' trained in China's Shaanxi

  5. Buildings collapse after subsidence

  6. Dense fog stages a choking comeback

  7. Incredible old photos

  8. CCTV hosts and their lovers

  9. China to build its first third-generation nuclear plant

  10. Nation's wind farms heading offshore

Most Popular


  1. Domestic lenders need global outlook
  2. Flu awareness still lacking in China
  3. 'China's demographic dividend disappearing'
  4. Purpose of Japanese politicians' China tour
  5. Why world focus on China's anti-corruption
  6. Japan PM: Door open for talks with China
  7. Y-20 marks transformation of PLA air force
  8. Is UK's withdrawal from EU a show?
  9. China's anti-missile test no threat to peace
  10. Children toy with new forms of leisure

What’s happening in China

Buildings collapse after subsidence in S China

  1. 91% of Shanghai's job-related crime is corruption
  2. China launches fire risk campaign
  3. 10 dead in Heilongjiang train-bus collision
  4. Hot debate on how to keep South warm
  5. Rewards for diners who leave nothing