The Chinese branch of the French fashion giant said Chanel products are safe and their production process meets industry regulations.
"Some natural products also contain these substances, which may lead to a reaction in some people with an allergic constitution," it said in a statement.
A 100ml bottle of Chanel N 5 is priced at 1,520 yuan (US$245) and a Chanel salesperson at Westgate Mall Isetan in Jing'an District said it is the best-selling product at the counter.
Perfume ingredients are not printed on packages as producers consider them to be company secrets.
Doctors suggested consumers test for an allergic reaction before they purchase a new perfume.