According to the People's Bank of China, the central bank, China has signed currency swap agreements worth more than 1.4 trillion yuan ($228 billion) with ASEAN countries.
From 2009 to June, yuan-denominated cross-border settlements had exceeded 1.12 trillion yuan. So far, the yuan can be exchanged directly with the Malaysian ringgit and the Thai baht.
In the first half the year, trade between China and ASEAN reached $210.6 billion, up 12.2 percent year-on-year. Last year, trade was $400 billion, nearly six times the level 10 years ago.
China is ASEAN's largest trading partner, while ASEAN is China's third-largest.
Song Hong, a senior researcher at the Institute of World Economics and Politics under the Chinese Academy of Social Sciences, said the regional currency cooperation is expected to stabilize trade in East Asia and help internationalize the yuan.
"China and ASEAN will face challenges when the US decides to quit the monetary easing policy, which may bring fluctuations in exchange rates, cross-border trade, property and equity prices," Song said.
Steve Brice, chief investment strategist of Standard Chartered Bank, said Asian currencies are likely to drop sharply when the US decides to quit the quantitative easing policy.
"Asian policymakers will need to address external imbalances or risk facing renewed currency weakness," Brice said.
On Thursday, Li also called to push forward economic integration in East Asia and complete negotiations on the Regional Comprehensive Economic Partnership before 2015.
The moves will make China and ASEAN serve as a main growth engine of the world economy, Li said.
The global economic recovery remains difficult, he said.
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