A Boeing airliner and another plane collided over the southern German state of Baden-Wuerttember, killing at least 140 people, German press reported.
A spokesman for the interior ministry of Baden-Wuerttemberg, speaking on customary condition of anonymity, said it was not immediately clear how many people were aboard the planes, but it was possible they were carrying mostly freight.
The official said the other plane was a Tupolev, but didn't elaborate. Internet sites describe the Tupolev as a Russian-built plane.
The planes went down near the city of Sigmariegen, near Lake Constance. aircraft wreckage was scattered for miles across the countryside, the spokesman said.
State German ARD television interviewed one man who described the crash as two large balls of fire in the sky.
No further information on the aircraft or passengers aboard was immediately available.