After nearly a week's delay, U.S.space shuttle Endeavour lifted off on Wednesday with a new crew to the International Space Station.
The launch, at 5:23 p.m. EDT (2123 GMT) from Kennedy Space Center in Florida, marks the 14th shuttle mission to the orbital outpost and the third shuttle mission this year. It is also the 18th flight of shuttle Endeavour and the 110th flight overall in U.S. space shuttle program.
Endeavour was slated to lift off last Thursday, but bad weatherand a leaky valve has forced U.S. space agency NASA to postpone the launch several times.
A multinational team of seven astronauts aboard the space shuttle include American Peggy Whitson, Russians Valery Korzun andSergei Treschev, the so-called Expedition Five crew, who will replace the three men now living on the space station.
The three members of Expedition Four -- Americans Daniel Burschand Carl Walz and their Russian commander, Yuri Onufrienko -- havebeen on the station since December 7, 2001. They will return to Earth with Endeavour.
During the scheduled 12-day mission, astronauts will perform three spacewalks to continue assembly of the space station, installing a Mobile Remote Servicer Base System onto the station'sMobile Transporter and replacing the wrist joint on the station's robot arm.