U.S. Senate Majority Leader Mitch McConnell conceded failure on Monday in efforts to repeal and replace former President Barack Obama's signature legislation, also known as the Obamacare.

"Regretfully, it is now apparent that the effort to repeal and immediately replace the failure of Obamacare will not be successful," McConnell said in a statement late Monday night.

His statement came closely after two more Republican senators announced opposition against the revised Better Care Reconciliation Act (BCRA), a GOP bill designed to overhaul the Obamacare.

The Senate will vote to take up the House-passed bill in coming days while calling for a repeal vote with a two-year delay for substitute, said McConnell.

Republican Senator Jerry Moran of Kansas and Mike Lee of Utah joined two other senators in opposing the GOP legislation, indicating that McConnell would not have the votes required to move the long-sought bill ahead.

Not long after Moran and Lee announced their defection, U.S. President Donald Trump urged Republicans to just repeal the country's current health care system and work on a new plan that starts from a "clean slate."