A 35-year old woman, who had been treated in a hospital in Jakarta since November 8 for having avian influenza, was dead earlier Tuesday, Indonesian Health Ministry said.
The death has put the total fatality to 57 out of 74 contracted people.
The woman is from Tanggerang, a city in outskirts of Jakarta.
"She died on Tuesday morning at 00:00 local time," an official of the anti-bird flu center of the ministry told Xinhua.
The woman was confirmed by the country's laboratory tests which were positive of having avian influenza on November 13, the official said.
She had contact with fowls in the past, he said.
Indonesia has become one of the front lines in the fighting against the H5N1 virus.
Experts have warned international community of the risks of the disease should Indonesia fail to prevent the highly pathogenic H5N1 virus from spreading.
Asia has been the hardest hit, with 135 out the 150 human deaths arising from bird flu since 2003 occurring in East Asia countries, according to the data from the World Bank.