Chelsea picked up a controversial win by beating Manchester City 2-0 on Saturday.
In the same day, Liverpool beat Everton in the Merseyside derby and Sunderland slipped to another defeat.
Last season's promotion winners Wigan Athletic and West Ham United met at The JJB Stadium, with The Hammers prevailing, while Aston Villa and Fulham played out a drab 0-0 stalemate.
Following a 1-0 defeat to Fulham last weekend, Chelsea were back to winning ways after a 2-0 win over 10-man City at Stamford Bridge.
Didier Drogba put the champions-elect in front on 30 minutes, but his second goal three minutes later was disputed as he used his arm to control the ball before volleying past David James.
City captain Sylvain Distin was booked for protesting the goal and was then sent off after the half time whistle for continuing his complaint with referee Rob Styles.
Chelsea had chances to put a further gloss on the scoreline, but will settle for a win which puts them 15 points clear of Manchester United, who play Birmingham on Super Sunday.
Liverpool overcame the early dismissal of Steven Gerrard to beat local rivals Everton 3-1 at Anfield. Gerrard was sent off on 18 minutes for two yellow cards in the space of 60 seconds.
Phil Neville's own goal put the hosts ahead just before half time and Luis Garcia added a second early into the second half.
Tim Cahill reduced the arrears before Everton substitute Andy van der Meyde was red carded for leading with the arm. Harry Kewell wrapped up the win with a fine strike.
Sunderland are still without a home win in The Premiership this season after Steven Reid's 15th minute solo effort kept Blackburn Rovers in the hunt for a UEFA Champions League spot as Mark Hughes' men move level on points with fourth-placed Tottenham.
Wigan and West Ham hold aspirations of gatecrashing the Uefa Cup and Alan Pardew's men snatched a last-gasp 2-1 victory.
Lee McCulloch's fierce drive put Wigan ahead just before half time, but Marlon Harewood capitalised on a Paul Scharner error to draw The Hammers level.
In injury time, Teddy Sheringham played in a low cross to the near post where Nigel Reo-Coker turned it past substitute keeper Mike Pollitt.
David O'Leary failed to significantly appease the Villa faithful as his struggling side were held 0-0 at home by Fulham.
Portsmouth's game with Arsenal, scheduled for teatime, was postponed due to a waterlogged pitch.