Defending champions North Carolina suffered a shock 65-60 loss to George Mason in the second round of the NCAA Tournament on Sunday.
The third-seeded Tar Heels ran out of steam in the second half as George Mason dominated play inside and held Tar Heels' standout Tyler Hansbrough to 10 points.
Lamar Butler scored 18 points to pace 11th seeded George Mason (25-7), which trailed 16-2 in the first five minutes of the game before overtaking the Tar Heels (23-8) with an 8-0 run to start the second half.
David Noel topped North Carolina with 22 points in the Washington Regional game at Dayton, Ohio.
Top seeds Connecticut and Memphis advanced, but 13th seeded Bradley upset fifth-seeded Pittsburgh 72-66.
Marcus Williams had 20 points with Rudy Gay 19 as Connecticut (29-3) squeezed past eight-seeded Kentucky 87-83 in the Washington Regional at Philadelphia. Patrick Sparks ignited Kentucky (22-13) with 28 points.
Memphis (32-3) crushed Bucknell 72-56. Four starters scored in double figures as the Tigers (32-3) won in the Oakland Regional game at Dallas.